b'Development of a StreamlinedState-of-the-art nuclear material profiling capabilities from nanoscale to Approach for Burnup andmesoscale enable fundamental research of nuclear material behavior. Microstructural AnalysisP re- and post-irradiation analysis of nuclear materials can be an expensive and time-consuming endeavor due to the unavoidable processes necessary of Nuclear Materials fromto gather accurate and precise results. An analysis can take anywhere from Nanoscale to Mesoscalea few days to multiple weeks depending on the number of samples, activity of the sample, complexity of the fuel type, and measurement requests. Conventional methods involve surface-based measurements, such as scanning electron microscopy, and destructive analytical techniques, such as inductively coupled plasma-mass spectrometry. While these methods have their inherent advantages, they also suffer from the inability to rapidly acquire local isotopic information about the fuel sample. This effectively limits the information that can be derived about PROJECT NUMBER:material performance. These factors prompt the need for an updated approach that 20A44-153 improves upon the pitfalls of traditional methods while making notable advances TOTAL APPROVED AMOUNT:in the analysis of nuclear materials. By merging the unique capabilities of atom $1,000,000 over 3 years probe tomography with a femtosecond laser ablation (LA)-laser induced breakdown spectroscopy (LIBS)-time-of-flight mass spectrometry (TOFMS), combined as LA-PRINCIPAL INVESTIGATOR:LIBS-TOFMS, this research increased sample throughput and provided a new method Mukesh Bachhavto quantitatively evaluate material performance based on three-dimensional isotopic CO-INVESTIGATORS: distributions in a specimen. Atom probe tomography offers the unrivaled capability Brandon Miller, INL to quantitatively analyze for isotopic composition on a three-dimensional atomic Daniel Wachs, INL scale. However, finding the most significant location to analyze can be a burdensome Dennis Keiser, INL process. LA-LIBS-TOFMS offers many advantages that can complement atom probe Jian Gan, INL tomography. Through rapid elemental and isotopic mapping of the samples surface Joey Charboneau, INL at micron resolution, LA-LIBS-TOFMS improves upon customary scanning electron Joshua Kane, INL microscopy analysis used to identify locations for focused ion beam sampling. Laura Sudderth, INL To enhance the complementary capabilities of these techniques, we validated a Lingfeng He, INL quantitative protocol for LA-LIBS-TOFMS that can be correlated to atom probe Matthew Jones, INL tomography data. Our research improved shortcomings of each method through a Nick Erfurth, INL joint approach, leaning on the concomitant nature of the techniques. Workflow developed for atom probe tomography mass spectrum using MATLAB toolbox for quantifying burnup from spent fuel. 26'